the reason why Pac spent so much time in the studio is because his music was his meduim, his way of communicating to the masses.
the use of twitter is a means of self publicity, and on a certain level twitter is also a form of media, and we all know what Pac's perspective was on the media.
i think Pac was above all the shit that was going on in the media. if anything, Pac used the media as a means unto himself, to gain publicity, create controversy, and sell records.
i doubt that Pac would have twittered, because he blogged everything down in his music instead, and created it into material to be sold. plus the use of twitter doesn't pay $$.