The more you fly the less you worry about I think, it just becomes second nature. I must have been on at least 16-17 flights last year. On my last two long haul flights I didn't even turn on the inflight entertainment system once to watch anything either. I just chilled out.
The only thing that I don't like is being exposed to every fucker's germs because of all the recirculating air, so sometimes I wear a bandana over my face. Especially if people nearby are sneezing or coughing, fuck that shit, I don't want your motherfucking germs.