When you make a statement like that, you're clearly inviting comparison between the two. Now, you're saying the two should not be compared.
If for once you want to actually sound like you know what you're talking about, it'd be a good idea to analyze Tupac's and Shakespeare's writing and show us evidence of Tupac using shakespearean style of prose, rhyme, and/or blank verse. In all honesty, I'm curious myself. I'm highly doubtful, though. At this point, I'm willing to say that E-40 is more "Shakesperean" than Tupac.