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I understand why he was so cautious but I think the drugs and his general lifestyle severely affected him. Look how calm he was during his stay in prison. In interviews he seemed more alert, articulate, and humble.
He had no reason to diss Nas on Bomb First. If Pac was alive right now, the two would be making plenty of dough.
At the end of the day, Pac wasn't as tough as he made out. You could see the Gemini in him, by the constant contradictions in his life. He went from extrvert to introvert, from humble to pure arrogant in seconds. He was only 25 and was still trying to find himself.